ISSN : 0975-9492


Open Access

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Title : Prominence of Preservative Counter balancing In Parenteral Formulations for Sterilization Investigation
Authors : Surya Sumanth G, Hindustan Abdul Ahad, ThanmayadivyaKumbarthi, Haranath Chintaginjala, Manjoor Ahamad Syed
Keywords : microbes, sterility, preservative, technique
Issue Date : Aug 2019
Abstract :
Anti-microbial preservatives (AMPs) has an important part in preventing the growth of microbes in multiple-dose parenteral formulations (PFs). Chemical preservation cannot keep products from spoiling, but they slow the spoiling process caused by microorganisms. Along with preservatives several excipients like buffers, polymers, antioxidantsetc., are added in the formulation. The preservative in the recovery agar or parenteral could artificially decrease the survival of viable cells thus the presence of preservative interfere with the sterility of PFs. It is important to counterbalance this residual activity to get accurate counts of survivors. The methods for inhibition of residual biocide are dilution and neutralization (dilution, chemical embarrassment, washing, and filtration) of the biocide. Neutralizer should inhibit the activity of AMPs and it should not become toxic later combining with the API. Several chemicals are used to inhibit the AMPs. The purpose of this research was to study the neutralization efficacy on a range of AMPs and its possibledeadliness for microbes that are used for antimicrobial preservation testing.
Page(s) : 220-223
ISSN : 0975-9492
Source : Vol. 10, No.8