| Abstract |
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The aim of the study is to develop a proniosomal gel for Nebivolol used for the treatment of hypertension that is capable of efficiently delivering entrapped drug over an extended period of time. The results showed that the type of lipid incorporated altered the entrapment efficiency of proniosomal gel and higher entrapment efficiency of 63.6 ± 2.5 % was obtained with the proniosomal gel prepared from Span 40. Different formulations of Proniosomal gel using Span 40 as surfactant were prepared by changing the ratios of surfactant: lecithin and the optimized formulations F1, F2, F3, F4, F5, F6 and F7 were further characterized. SEM studies revealed uniform size and spherical shape of proniosomal gel, FTIR studies revealed that there was no interaction between the drug and excipients. In-vitro experiments of the F1, F2, F3, F4, F5, F6 and F7 formulations showed a release rate of 73.2, 51.8, 52.7, 78.3, 65.8, 71.4, 58.2 respectively. Hence formulation F4 was optimized as the drug release was found to be highest i.e., 78.3 % in 7 hours. |
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