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ABSTRACT
| Title |
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DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR IRBESARTAN AND ATORVASTATIN BY SIMULTANEOUS EQUTION SPECTROSCOPIC METHOD |
| Authors |
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ParasVirani, RajanitSojitra, HasumatiRaj, Vineet Jain |
| Keywords |
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Irbesartan, atorvastatin, simultaneous estimation, Simultaneous equation method, analysis method. |
| Issue Date |
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March 2015 |
| Abstract |
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A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Irbesartan and atorvastatin in synthetic mixture usingsimultaneous eqution Method.In this spectroscopic method, 226.00 nm and 246.00 nm wavelengths were selectedfor measurement of absorptivity. Both the drugs show linearity in a concentration range of 05-30 µg/ml at theirrespective ?max. Accuracy, precision and recovery studies were done by QC samplescovering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy,precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.033µg/ml and 0.125 µg/ml for Irbesartan and atorvastatin, respectively. The limit of quantification was 0.1008 µg/ml and 0.3792 µg/ml for Irbesartan and atorvastatin, respectively. Recovery of Irbesartan and atorvastatin were found to be 99.75 % and 99.52% respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid,simple, accurate and also sensitive and specific by no heating and no organic solvent extraction. |
| Page(s) |
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519-525 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 6, No.3 |
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