ISSN : 0975-9492


Open Access

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Title : Antioxidant activity of Gloriosa superba against paracetamol induced toxicity in experimental rats.
Authors : Mrs. Indhumathi.T, Ms. Sreetha erattarakkal
Keywords : Gloriosa superba, Antioxidant, Lipid per oxidation, Paracetamol
Issue Date : December 2011
Abstract :
Paracetamol was chosen to induce hepatotoxicity in rats. Gloriosa superba tubers were extracted and used for the treatment against paracetamol induced toxicity. In this study, the animals were divided into three groups comprising of six animals each. Group I served as a control, group II animals were administered with paracetamol(200 g/kg) orally for 10 days, group III animals were received Gloriosa superba tubers aqueous extract (500 mg/kg/bw/po) for 5 days followed by paracetamol(200 g/kg) orally for 2 days. Level of LPO was found to be increased during paracetamol intoxication with concomitant decrease in the activity of enzymic and non- enzymic antioxidants. The antioxidant enzyme levels were reverted to near normal in Group III rats which results the antioxidant activity of Gloriosa superba.
Page(s) : 212-215
ISSN : 0975-9492
Source : Vol. 2, No.12