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ABSTRACT
| Title |
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FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF CANDESARTAN CILEXETIL TRANSDERMAL FILMS |
| Authors |
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Pooja Tompe, Priyal Jangla, Milind Bhitre, Aparna Palshetkar |
| Keywords |
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Candesartan Cilexetil, matrix type transdermal system, HPMC K10, PVP K5, propylene glycol, folding endurance, in vitro permeation study. |
| Issue Date |
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Jan 2021 |
| Abstract |
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Transdermal drug delivery system is a technology in which drug is entrapped in a thin polymeric film or patch which when comes in contact with skin delivers the drug into the surrounding tissue and systemic circulation. Candesartan Cilexetil is an antihypertensive drug used in the treatment of high blood pressure and congestive heart failure. It exhibits poor water solubility, very low oral absorption and hepatic first pass metabolism. To enhance its oral bioavailability and avoid liver metabolism, transdermal films of Candesartan Cilexetil were formulated in this present research work. The objective was to prepare and evaluate transdermal films using different ratios of polymers with varying concentration of plasticizer. Matrix type transdermal films containing combination of hydroxypropyl methylcellulose K10: polyvinyl pyrrolidone K5 and ethyl cellulose: polyvinyl pyrrolidone K5 in various ratios, plasticizer propylene glycol and penetration enhancer oleic acid were prepared using solvent casting technique. The selected formulations were evaluated for various physicochemical parameters like appearance, surface pH, folding endurance, weight variation, thickness, % swellability, moisture content, drug content and in vitro permeation studies. The films containing hydroxypropyl methylcellulose K10: polyvinyl pyrrolidone K5 were transparent, homogenous, capable of bending without breaking, having smooth texture and compatible with the skin pH. The observations signified good quality and uniformity in transdermal films. In vitro drug permeation studies showed sustained release till 10 hours, the graph plot of percent cumulative drug release versus time (hrs) depicted zero order kinetics. Transdermal delivery of Candesartan Cilexitil can be one of the promising options to maximize the antihypertensive therapy by reducing dosing frequency, improved patient compliance and bioavailability in disparity to conventional oral delivery. |
| Page(s) |
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10-15 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 12, No.01 |
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