ISSN : 0975-9492


Open Access

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Title : Transdermal Delivery of Ondansetron Hydrochloride in the management of Hyperemesis Gravidarum
Authors : Snigdha Bhardwaj, Sonam Bhatia, Shaminder Singh
Keywords : Diffusion, hyperemesis gravidarum, in-vitro drug release, penetration enhancer, stability, transdermal patch
Issue Date : Aug 2020
Abstract :
Transdermal route has always been a route of choice for those drugs having limitations through oral route. Transdermal delivery of Ondansetron Hydrochloride (HCl) is one of the potential strategies, capable of maximizing the drug performance in patients with Hyperemesis Gravidarum facing issues with oral drug delivery. Current study focused on the development of matrix transdermal patches of Ondansetron HCl using solvent casting method with combination of different polymers and eugenol as penetration enhancer followed by physical characterization for various parameters such as weight variation, folding endurance, moisture content, moisture uptake, drug content, tensile strength, elongation break test, FT-IR studies, in-vitro percent drug release, stability studies. The result suggested that formulation F3 exhibited optimum results in respect to physical evaluation and in-vitro drug release exhibited release in concentration independent manner (62.2±1.3% upto 8 hrs). All formulations followed zero-order kinetics and Higuchi’s model values showed ‘diffusion’ as predominant release mechanism. FT-IR analysis revealed that there are no potential chemical interactions between the drug and the polymers. Stability studies revealed promising result and the formulation (F3) was found to be stable at 40±2°C and 75±5% RH. The study indicated that transdermal delivery of Ondansetron HCl is a suitable way to increase therapeutic effectiveness.
Page(s) : 206-214
ISSN : 0975-9492
Source : Vol. 11, No.08
PDF : Download
DOI : 10.21817/ijpsr/2020/v11i8/201108004