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ABSTRACT
| Title |
: |
Cefixime Niosomes: Fabrication and characterization |
| Authors |
: |
Sruthi Marthadu, Jyoshna Medindla |
| Keywords |
: |
niosomes, Spans, Cefixime, Cholesterol, Methanol, Diethyl ether |
| Issue Date |
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Aug 2019 |
| Abstract |
: |
The authors aimed to fabricate and characterizethe site precise delivery of Cefiximeniosomesto avoid disturbances in gastric dissolution and absorption for desired therapeutic response. Cefiximeniosomes were fabricated by an Ether injection procedure with innumerable proportions of Cefixime, cholesterol and Sorbitans (Span 40, 60 and 80). The fabricated niosomes were characterized for compatibility studies with excipients used, vesicular shape, size, entrapment efficiency, drug content, and in-vitro drug release. The outcomesdiscovered that the primedniosomes passes and satisfies all the physicochemical characterizations done. The study concludes that Cefixime can be formulated as niosomes by ether injection techniques for enhanced absorption of drug. |
| Page(s) |
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224-228 |
| ISSN |
: |
0975-9492 |
| Source |
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Vol. 10, No.8 |
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