ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Assay of Memantine Hydrochloride by UV Spectrophotometer
Authors : Asra Ali Bahazeq, Wasfiya Noor Syeda, Nashra Fatima Isba, MD. Muzaffar-Ur-Rehman, Uzma Amatul Baqi
Keywords : Memantine hydrochloride, Alzheimer’s disease, ICH guidelines, Validation,
Issue Date : Jan 2019
Abstract :
Memantine hydrochloride is a class of N-Methyl-D-Aspartase receptor antagonist used in the treatment of Alzheimer’s disease. The main aim of the present study was to develop a method to determine Memantine hydrochloride in tablet formulation which is simple, sensitive, precise and economical as per ICH guidelines. The method was validated at λ max of 254nm. Beer-Lambert’s was obeyed between the concentration ranges of 0.2-0.6µg/ml. A good linear relationship with correlation co-efficient of 0.998 was obtained and the LOD and LOQ values were 0.48µg/ml and 1.48µg/ml respectively. The method was also employed on the tablet formulation (Namenda) and the recovery was found to be 99.8%.
Page(s) : 27-30
ISSN : 0975-9492
Source : Vol. 10, No.1