| Abstract |
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Background: Diabetes is a chronic metabolic disease. All over the world there has been substantial rise in number of diabetic patients and may experience an increased risk of cancer. Objectives: Primary - Associate the compiled data from systematic reviews. Secondary - Collect data from databases, journals, modern texts, websites & ayurvedic classics. Material and method: The systemic literature search includes databases, journals, periodicals, Ayurvedic classics, web sites like pub med, DHARA, AYUSH portal with the term ‘Diabetes mellitus’, ‘risk of cancer’, ‘madhumeha’ & ‘prameha’. Result: All Meta analyses reporting a significant increased risk among diabetes patients for liver, pancreatic, oesophageal, colorectal, endometrial, breast, kidney and bladder cancer with the risk ratio and confidence interval. In madhumeha vyadhikshamatva [immunity] is a major casualty. Oja plays an active part as dushya in the pathogenesis of madhumeha and its deficiency characterizes vikar avighata abhava. Dosha, dushya, shatkriyakala, dhatukshayata, vyadhikshamtva abhaav these all possible factors in pathogenesis of madhumeha are responsible for increase a risk of cancer in patient. Conclusion: The systematic review of Meta analytical studies associated with all possible determinants in madhumeha pathogenesis confirms the result of increased cancer risk in diabetes mellitus patients. |
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