ISSN : 0975-9492


Open Access

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Title : In vitro antitrypanosomal activity of Breonadiasalicina on Trypanasomabruceibrucei
Authors : Ali Sani, Umar Abdullahi Zakariyya, Asmau Mahe, Deepa Singh, Milli Jain, Fatima Hassan
Keywords : Trypanasomiasis, Breonadiasalicina, In vitro, Activity
Issue Date : Aug 2018
Abstract :
Objectives: Trypanosomiasis is associated with human morbidity and mortality.The aim of the study was to evaluate the anitrypanocidal activity of 70 and 100% ethanolic extract of B. salicina on Trypanasomabruceibrucei. MaterialsandMethods: The B. salicina extracts leaves were screened for phytochemicals and were subsequently subjected to in vitro antitrypanasomal activity bioassay. Results: The results showed that the extracts of B. salicina contained alkaloids, saponins, tannins, carbohydrates and flavonoids, with the exception of alkaloids which was absent in 100% ethanolic extract. In addition, both the extract possess antitrypanasomal activity with 70% having a higher potentials Conclusion: The antitrypanasomalactivity of B. salicina was seen to be concentration and time dependent. Further research should be carried on the potentials of other plants should be screened for potential antitrypanasomal activity.
Page(s) : 103-107
ISSN : 0975-9492
Source : Vol. 9, No.08