| Abstract |
: |
Through the years, cyclodextrins have been used in order to increase the solubility of insoluble drugs in aqueous solutions. The aim of the present work was to improve the solubility of Atorvastatin, as a lipid-lowering agent. Inclusion complex of Atorvastatine in β-cyclodextrin was prepared in polymer dispersion using four different methods: physical mixture, kneading method, Freeze-drying and co-evaporating method with stoichiometric molar ratio 1:1 and 5% (W/W) polymers; drug content estimation found that co-evaporating is the best one of them. Formulations with different polymers concentrations 2.5%, 5%, 7.5%, 10%, 15% and 20% (W/W) are prepared with co-evaporating method and in-vitro dissolution study of pure drug, β-cyclodextrin–Atorvastatine inclusion complex and all formulations have been released, the formulation which presents the best dissolution rate was 5% of PEG1500, the dissolution rate has attended more than 99.70%. |
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