ISSN : 0975-9492


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Title : Effect of Polymers Dispersions on the Inclusion Complexe Formation Between β-Cyclodextrin and Insoluble Drugs. Case Study: Atorvastatin Solubility Enhancement in the Biological Conditions of the Blood Medium (In-Vitro Dissolution Study)
Authors : NAIT BACHIR Yacine
Keywords : Polymer Dispersion, Inclusion Complex, β-cyclodextrin, Insoluble Drug, in-vitro dissolution.
Issue Date : Jun 2018
Abstract :
Through the years, cyclodextrins have been used in order to increase the solubility of insoluble drugs in aqueous solutions. The aim of the present work was to improve the solubility of Atorvastatin, as a lipid-lowering agent. Inclusion complex of Atorvastatine in β-cyclodextrin was prepared in polymer dispersion using four different methods: physical mixture, kneading method, Freeze-drying and co-evaporating method with stoichiometric molar ratio 1:1 and 5% (W/W) polymers; drug content estimation found that co-evaporating is the best one of them. Formulations with different polymers concentrations 2.5%, 5%, 7.5%, 10%, 15% and 20% (W/W) are prepared with co-evaporating method and in-vitro dissolution study of pure drug, β-cyclodextrin–Atorvastatine inclusion complex and all formulations have been released, the formulation which presents the best dissolution rate was 5% of PEG1500, the dissolution rate has attended more than 99.70%.
Page(s) : 74-82
ISSN : 0975-9492
Source : Vol. 9, No.06