ISSN : 0975-9492


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Title : Acute and Sub Chronic (91 days) dermal toxicity study of Mahanarayana taila in Wistar rats
Authors : Sanjaya Kumar Y.R., Sudesh Gaidhani N., Thamizh Selvam. N., Deep V.C., Radhakrishnan P.
Keywords : Mahanarayana taila, wistar rats, dermal toxicity
Issue Date : Feb 2018
Abstract :
Mahanarayana taila, a compound Ayurvedic formulation was evaluated for safety in Wistar rats by acute and sub chronic (91 days) dermal toxicity studies. The test drug was applied externally and the animals were observed for the physical and clinical synptoms of toxicity in comparision to animals in control group. Neither mortality nor signs of toxicity were observed in Wistar rats during both the studies. Hematological, serum chemistry and qualitative urine examination showed no evidences of systemic toxicity. Histopathology of skin and internal organs did not reveal structural changes suggestive of toxicity upon gross examination and histopathology investigation. Mahanarayana taila was found to be safe upon upon single and repeated dermal exposure in wistar rats during the study.
Page(s) : 29-34
ISSN : 0975-9492
Source : Vol. 9, No.02