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ABSTRACT
| Title |
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The Effect of Polyvinylpyrrolidone (PVP) on Ocular Gel Forming Solutions Composed of Gellan and Calcium Gluconate |
| Authors |
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KENNETH REED, NATE BERGER |
| Keywords |
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Ocular drug delivery, Gel forming solutions, Gellan, In situ gelation, Diffusional release. |
| Issue Date |
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Feb 2018 |
| Abstract |
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Purpose: This study focuses on the optimization of the ocular in situ gel strength of gellan plus calcium gluconate gel forming solutions both with and without polyvinylpyrrollidone. Additionally, it is of interest to investigate the diffusional release of tryptophan (acting as a model drug) from these same types of formulations. Methods: Aqueous formulations of gellan, calcium gluconate, and polyvinylpyrrolidone were prepared at varying concentrations and were measured for viscosity characteristics indicative of the ability to be administered from common ophthalmic packaging and the ability to form gels upon initial contact with tear fluid. Linear regression and multi-variate, nonlinear regression analysis fit equations were used to calculate the highest obtainable ocular in situ viscosities for gel forming solutions (with and without polyvinylpyrollidone) that can be administered from common ophthalmic packaging. Nonparametric matched pair analysis was used to conduct a statistical comparison of gellan and calcium gluconate formulations both with and without polyvinylpyrrolidone. Results and Conclusions: The data indicates that the addition of polyvinylpyrrolidone to gellan and calcium gluconate preparations increases the in situ gel strength of the formulations while still retaining the ability to be dispensed from an ophthalmic bottle. The diffusional release of tryptophan was found to be significantly slower from gellan and calcium gluconate gel forming solutions when compared to a simple tryptophan solution. |
| Page(s) |
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20-28 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 9, No.02 |
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