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ABSTRACT
| Title |
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Effect of hydrophilic polymer on bouancy of floating tablet prepared by wet granulation technique using Musa paradisiaca starch |
| Authors |
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SUPRIYA SANDHAN, NILIMA THOMBRE, SAGAR AHER |
| Keywords |
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Floating tablet, Musa paradisiaca L., Hydrophilic polymer, Binder, Optimization |
| Issue Date |
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Oct 2017 |
| Abstract |
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The purpose of research was to develop and optimized Floating tablet of Metoprolol succinate using hydrophilic polymer (HPMC & Carbopol) by wet granulation method by using Musa paradisiaca L. starch as binding agent. A 32 full factorial design was applied to systemically optimize the drug release profile and floating lag time by using Design Expert Software 7.0. As the concentration of HPMC increases in formulation the floating lag time decreases and % drug release is retard as the concentration of Carbopol 971P increases. As per hardness and friability of floating tablet, it was assure Musa paradisiaca starch shows good binding property and longer floating time (24 hr.) favourable for sustained drug delivery of active pharmaceutical ingredient. Wet granulation method is useful for preparation of floating tablet that valuable for the buoyancy and gastro retentive drug delivery. |
| Page(s) |
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195-201 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 8, No.10 |
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