ISSN : 0975-9492


Open Access

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Title : “Design and Evaluation of CelecoxibMicrosponge”
Authors : Annu.P, Anand Kumar Y
Keywords : Microsponge, Eudragit, Ethyl cellulose, Carbopol, In vitro studies.
Issue Date : October 2016
Abstract :
Purpose: Celecoxibmicrosponges systems were developed to control the drug release for topical application. Methods: Celecoxibmicrosponges were prepared using Eudragit RS100 and ethyl cellulose by quasi emulsion solvent diffusion method. Prepared microsponge systems were evaluated for production yield, loading efficiency,drug content, drug interaction studiesand in vitro drug release studies. Optimized microsponges were incorporated into carbopol gels and evaluated for in vitro drug release and skin irritation tests. Results: The FTIR results suggest no interaction between the drug and excipients. The drug content was uniform and no significant difference was observed for production yield and loading efficiency amongst all the formulations. The release was found to be steady after 2 h and was extended up to 8 h with sustained action and as the concentration of the polymer increases the drug release was decreases. Neither edema nor symptoms of adverse affects were observed in skin irritation studies. Conclusion:Celecoxibmicrosponges were conveniently prepared with method adapted and the results were found to be reproducible.
Page(s) : 396-405
ISSN : 0975-9492
Source : Vol. 7, No.10