ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Evaluation of Anti-Hyperglycemic Activity of Kariveppilai Churnam in Alloxan Induced Diabetic Rats
Authors : C. Mary Sharmila, A.Faridha, N.Chidambaranathan
Keywords : Diabetic complications, Alloxan, Kariveppilai churnam, Siddha
Issue Date : June 2015
Abstract :
Objective - The present investigation is undertaken to study the effect of Kariveppilai churnam on changes in Body weight, Plasma glucose, Plasma Insulin, Hemoglobin and glycosylated hemoglobin and lipid profile in alloxan induced Diabetic Rats. Methodology - The raw materials of the compound herbal drug were purchased, identified and pulverized into powder form. The trial drug was administered to alloxan induced diabetic male albino rats. The rats were divided into 5 groups with 6 rats in each group. Group 1, 2 and 3 were normal control, toxic control and diabetic control respectively. Group 4 and 5 received the trial drug at a dose of 250 mg/kg and 500 mg/kg orally respectively once a day. The anti-hyperglycemic activity of the trial drug was evaluated using the parameters of blood glucose, hemoglobin, glycosylated hemoglobin, plasma insulin, total cholesterol, triglycerides , HDL and phospholipids. Results The administration of the trial drug at doses of 250 mg/kg and 500 mg/kg of the body weight of the diabetes induced rats showed significant decrease in the above mentioned elevated parameters. Glipizide (10mg/kg) was used as the reference standard. Conclusion- From the results it can be observed that trial drug at a dose of 250 mg/kg and 500 mg/kg has protective effect against alloxan induced diabetes and its complications. The findings suggest that kariveppilai churnam possess anti-atherogenic property along with anti hyperglycemic activity.
Page(s) : 965-970
ISSN : 0975-9492
Source : Vol. 6, No.6