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ABSTRACT
| Title |
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FORMULATION, OPTIMIZATION AND EVALUATION OF LIQUISOLID TABLETS CONTAINING TADALAFIL |
| Authors |
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Malani Ketan Ashokbhai, Dr. Tejash Seresiya |
| Keywords |
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Liquisolid tablets, Tadalafil, PEG 800, Avicel pH 102, Aerosil200, PVP k30 |
| Issue Date |
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June 2015 |
| Abstract |
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Objective:- The aim of our study was to improve the avaibility of Tadalafil a practically insoluble erectile dysfunction drug. As a model drug by using liquisolid technique. The effect of powder susstrate composition on the flowability and compressibility of liquisolid compacts were evaluated. Specifically, several liquisolid formulations, containing 10mg Tadalafil, which containing different carrier to coating ratios in their powder substrates and a fixed liquid medication, were prepared. The dissolution profiles of Tadalafil liquisolid tablets were determined according to USP method. The obtained dissolution profile were compared to that of a commercial product. In the present study, the formulated liquisolid systems exhibited acceptable flowability and compressibility. In addition, liquisolid tablets displayed significant enhancement of the dissolution profiles compared to this of commercial one. Results and discussion: Prepared liquisolid tablets were evaluated for pre-compression and post-compression parameters. Angle of repose, carr’s index and hausner’s ratio were found to be in acceptable range. Hardness, friability, disintegration time, were found to be in specified range for all formulations. In-vitro drug release of liquisolid tablets were higher compared to control and marketed tablets due to its less contact angle and more wettability. Significantly improved dissolution profile was observed for all liquisolid formulation as compared to that of marketed formulation as indicated from in-vitro dissolution study (108.33%) which was due to presence of polyethylene glycol which increase fluid penetration in to formulations. Moreover the desirability value of various dependent variables was found to be nearer to one. Performance of optimized formulation (A1) remained consistence at the end of stability study. |
| Page(s) |
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991-1001 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 6, No.6 |
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