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ABSTRACT
| Title |
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OPTIMISATION OF CHRONOMODULATED DOSAGE FORM FOR ASTHMA USING FULL FACTORIAL DESIGN |
| Authors |
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SARDA R.R, NITURE N.T, KENDRE D.G, SATPUTE K.L. |
| Keywords |
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Pulsatile, Full factorial design, Press coated, Asthma |
| Issue Date |
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June 2015 |
| Abstract |
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Chronotherapy is growing treatment method in various diseases. Various diseases like asthma, hypertension, and arthritis show circadian variation, that demand time scheduled drug release for effective drug action. In Asthma like diseases which follow circadian rhythms, it is necessary to modulate the drug release in synchrony with the circadian rhythm of nocturnal asthma. Different polymers like Ethyl cellulose 10, 20, 45 cps, Compritol, Sodium alginate, Sodium CMC and LH-21 were tried. The combination of Eudragit RSPO and HPMC K4M was selected for the study based on lag time and release characteristics. On the basis of the trial batches and their evaluation parameters, concentrations of the polymers were decided and the 23 full factorial design was applied for the formulation of tablets. Lag time prior to drug release and cumulative percentage drug release at 3hrs and 6hrs were selected as responses. Results revealed that both, the coating composition and coating level, are significant factors affecting drug release profile. |
| Page(s) |
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1015-1022 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 6, No.6 |
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