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ABSTRACT
| Title |
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“PREPARATION OF SOLID DISPERSION OF POORLY WATER SOLUBLE DRUG FORMULATION AND CONSIDERATION” |
| Authors |
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Mr.Godge G.R., Miss.Labade S.P. |
| Keywords |
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Solid dispersion, furosemide, eudragit, dissolution enhancement, control release tablet. |
| Issue Date |
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May 2015 |
| Abstract |
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This article investigates enhancement of the dissolution profile of furosemide using solid dispersion (SD) with eudragit(RLPO & RSPO) & also control it’s by using solvent evaporation technique. 1: 0.5(w/w) 1:1(w/w) ,1:1.5 solid dispersions were prepared by solvent evaporation technique using solvent water and methanol in 1:1 ratio. Dissolution studies using the USP paddle method were performed for solid dispersions of furosemide at 37 ± 0.5 ° C and 55 rpm in simulated gastric fluid (SGF) of pH 1.2. Fourier transformer infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. Tablets were formulated containing solid dispersion products and compared with pure drug . IR spectroscopy, XRD, and DSC showed change in the crystal structure towards amorphous one of furosemide (FRMD). Dissolution of furosemide improved and release is controlled significantly in solid dispersion with the ratio 1:1.5 of eudragit RLPO & RSPO . Tablets containing solid dispersion exhibited better dissolution profile than pure drug. Thus, the solid dispersion technique can be successfully used for improvement of dissolution of furosemide as well as control it’s release. |
| Page(s) |
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897-903 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 6, No.5 |
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