ISSN : 0975-9492


Open Access

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Title : Evaluation Of Antiinflammatory And Antinociceptive Properties Of L.siceraria Aerial Parts
Authors : P. Saha, U. K. Mazumder, P. K. Haldar
Keywords : Anti-inflammatory activity, Antinociceptive activity, L.siceraria, Cucurbitaceae, carrageenan.
Issue Date : May 2015
Abstract :
Purpose: The objective of the present study was to evaluate the anti-inflammatory and antinociceptive activity of the methanol extract of Lagenaria siceraria aerial parts (MELS) at the doses of 200 and 400 mg/kg body weight. Methods: Hot plate, tail immersion and acetic acid induced writhing response in mice were used to assess antinociceptive activity. Antiinflammatory property was studied using acute inflammatory models (such as, carrageenan, dextran and histamine-induced rat paw oedema) as well as on chronic inflammatory model (cotton pellet granuloma test). Results: Potent antinociceptive activity was exerted by the extract. In case of acute inflammatory models, MELS inhibited rat paw oedema in dose dependent manner. In the chronic inflammatory model, daily dosing of 400 mg/kg of the extract significantly suppressed granuloma formation. Conclusion: Thus the extract of L. siceraria exhibited significant anti-inflammatory and antinociceptive activities.
Page(s) : 874-881
ISSN : 0975-9492
Source : Vol. 6, No.5