ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : HISTOPATHOLOGICAL EXAMINATION AND CHANGES IN SERUM ELECTROLYTES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS OWING TO TREATMENT WITH ETHANOL EXTRACT OF VITEX DONIANA LEAVES
Authors : Yakubu, O.E., Nwodo, O.F.C.
Keywords : histopathology, streptozotocin-induced diabetic, Vitex doniana.
Issue Date : May 2015
Abstract :
In this study, the antidiabetic effects, histopathological examination and changes in serum electrolytes of Vitex doniana leaves treatment on Wistar albino rats was studied. V. doniana leaves were extracted using ethanol and water as solvents. Diabetes mellitus was induced with a single intraperitoneal dose of 50 mg/kg b.w of streptozotocin and treatment of diabetic and normal rats was carried out using the doses of 25 and 50 mg/kg b.w for each extract. Fasting blood sugar (FBS), Na+, K+, CL-, HCO3- and Ca2+ were analysed as well as the histopathological examination of the liver and kidney. At 25 and 50 mg/kg, the extracts significantly (P<0.05) reduced the FBS (groups 3, 4 and 5) compared to control (group 2). Treatment of diabetic rats with 25 and 50 mg/kg (groups 3, 4 and 5) revealed non-significant (p<0.05) increase in the electrolyte concentrations compared to control (group 2),while histopathological examination of liver and kidney showed mild toxicity on the tissues. However, these results suggest that ethanol and aqueous extracts of the leaves of Vitex doniana have remarkable anti-diabetic effects with promising clinical relevance of reducing diabetic complications.
Page(s) : 830-835
ISSN : 0975-9492
Source : Vol. 6, No.5