| Abstract |
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Purpose: Experimental studies in alloxan-induced diabetic animals have demonstrated several abnormalities upon induction such as physiological, biochemical and histological alterations. In this present study, the influences of graded doses of soya bean oil supplementation for 4weeks on some biochemical parameters in alloxan-induced diabetes in rats were determined. Methodology: Sixty (60) male albino rats weighing about 240-260g were divided into 6 experimental groups of 10 rats per group viz: I, II, III, IV, V and VI. Group I serve as male control, group II serve as diabetes control which were fed with normal rat chow while rats in the test group were fed with graded doses of soya bean oil supplements and water ad libitum for 4weeks, at the end of the supplementation, plasma lipid profile and glucose level were determined. Results: All the diabetic induced rats had significantly higher (p<0.01) Glucose, Total cholesterol, Triglyceride, LDL-C, VLDL-C, but lower HDL-C levels than all the non-diabetic rats. The data obtained after supplementation revealed that soya bean oil significantly reduced the glucose level and ameliorated the lipid profile with attendant decrease in glucose, total cholesterol, triglyceride, LDL-C, VLDL-C levels, but with a corresponding increases in HDL-C levels respectively when compared to alloxan-induced diabetic rats. Conclusion: The observation of significant changes in plasma lipid profile, glucose level might be as a result of supplementation with soybean oil. It is therefore concluded that Soya bean oil possess significant antidiabetic activity that can improve the physiological and biochemical parameters which are abnormally altered due to diabetes mellitus. |
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