ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Comparative studies of efficacy and effect on oxidative stress of atenolol and candesartan in the hypertensive patients of North East India
Authors : S.Tamuli, S.Kakati, S.Das
Keywords : Comparative efficacy, hypertensive status, oxidative stress, serum levels.
Issue Date : April 2015
Abstract :
The present study was carried out to investigate the comparative efficacy of - blockers and Angiotensin receptor blockers. This study was carried out using Atenolol and candesartan which are frequently prescribing to the hypertensive patients of the North Eastern part of India. An attempt was made to evaluate the comparative efficacy and estimated the serum level of superoxide dismutase (SOD), serum glutathione (GSH), lipid peroxidation product, malondialdehyde (MDA) and total antioxidant status (TAS). The study consisted of 60 subjects (20 volunteers and 40 patients). 40 patients were randomized and divided into two groups to receive either Atenolol (50-100mg) or Candesartan (8-16mg) respectively. Patients were examined for blood pressure, fasting blood sugar level (FBS), lipid profiles, serum levels such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate (SGOT) and also estimated enzymatic / non enzymatic antioxidant levels before and after treatment of antihypertensive drugs. The result of the present study shows that both the drugs have significant effect (P<0.001) on decreasing systolic blood pressure and diastolic blood pressure. The level of MDA was decreased significantly (p<0.01) with Candesartan.The levels of SOD, GSH and TAS were significantly (p<0.01) increased after Candesartan therapy. By this study result, it was found that both the drugs possess similar antihypertensive action whereas Candesartan possesses additional benefit in reducing oxidative stress.
Page(s) : 622-626
ISSN : 0975-9492
Source : Vol. 6, No.4