ISSN : 0975-9492


Open Access

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Title : “Formulation and evaluation of starch acetate matrix tablets in combination with surfactants for controlled release”
Authors : Mahesh Kumar Vishwanadha, B. Shravan Kumar, Rajasri. Ch., Mounika.G,Ramya.D, Saikrupa.B
Keywords : Controlled release, Matrix tablet, Ibuprofen, Starch acetate, Sodium Lauryl Sulphate.
Issue Date : April 2015
Abstract :
In the present study, an attempt has been made to evaluate starch acetate in combination with surfactant for the controlled release profile of drug from matrix system. Ibuprofen was used as a model drug to evaluate its release characteristics from different matrices. Starch acetate was synthesized, characterized and then employed in the matrix tablets as a hydrophobic polymer in different ratios in combination with SLS. Formulated tablets were characterized for parameters like thickness, weight variation, drug content uniformity, hardness, friability and in-vitro release rate profile and the release data were analysed as per various kinetic models. From the data it was found that the release was following first order kinetics for all the formulations except F8 release profile of which followed zero order and the mechanism of release was found to be Non-fickian diffusion for all the formulations.
Page(s) : 718-722
ISSN : 0975-9492
Source : Vol. 6, No.4