| Abstract |
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Purpose: Over the past decade, there has been an increasing interest in using nanotechnology for lung cancer therapy.Recently, Chitosan based nanoparticles have received much attention by the researchers owing to its biodegradability, biocompability and the ability to deliver a wide range of drugs. Method: The aim of the present study was to formulate and evaluate chitosan nanoparticles containing Doxorubicin HCl. The chitosan nanoparticles were prepared by w/o emulsion method. Result: The drug loading capacity of the nanoparticles varied from 49.78 to 53.31 which depend on the concentration of drug in each formulation. The mean particle size of the selected batch was 129.9 nm with a polydipersity index 0.230 and zeta potential was found to be 43.9 mV. The study on in vitro release of all drug loaded batches in pH 7.4 phosphate buffer exerted a bi-phasic release pattern with and initial burst effect followed by a sustained release. The release kinetics studies showed that the release was Zero order diffusion controlled.Conclusion: Based on the observations, it can be concluded that the formulated nanopartilculate delivery system of Doxorubicin HCl exhibiting sustained release properties for a period of 24 hour, this may reduce concentration of drug to be administered along with frequency of dosing, thereby minimizing the occurrence of side effects, improve bioavailability, and increase the effectiveness of the drug. |
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