ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : FORMULATION AND EVALUATION OF A MONOLITHIC DRUG-IN-ADHESIVE TYPE PATCH CONTAINING TENOXICAM
Authors : S. Ramkanth, S. Jayaprakash, T. Vimalakannan
Keywords : Transdermal, Tenoxicam, Solvent Casting Technique, Patches
Issue Date : April 2015
Abstract :
Tenoxicam (TX) is a well-established nonsteroidal anti-inflammatory agent with analgesic actions achieved by inhibiting prostaglandin synthesis. Administration of tenoxicam through the transdermal route offers many advantages over the oral dosage form as it avoids the problems associated with the other routes of administration, such as improving patient compliance in long term therapy, bypassing first pass metabolism, sustaining drug delivery, maintaining a constant and prolonged drug level in plasma, minimizing inter- and intra-patient variability, and making it possible to interrupt or terminate treatment when necessary. The aim of the present investigation was to formulate and evaluate a monolithic drug-in-adhesive type patch containing Tenoxicam (TX) using various polymers like Hydroxy Propyl Methyl Cellulose (HPMC), Ethyl Cellulose (EC) and carbopol and plasticizers by solvent casting technique. The prepared transdermal patches were then evaluated for their physicochemical properties. The in-vitro release studies revealed that the release was sustained upto 24h and it follows zero order kinetics (r2 0.998). Finally, the patch formulation containing TX (G 7) selected through our in-vitro study. As a patient friendly and once a day dosing therapeutic system, the Transdermal patches incorporating TX could be promising in the pasture of Controlled drug delivery.
Page(s) : 654-659
ISSN : 0975-9492
Source : Vol. 6, No.4