ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Stability assessment of isoniazid and rifampin liquid dosage forms in a national referral center for tuberculosis
Authors : Shadi Baniasadi, Nahid Shahsavari, Rocsanna Namdar, Farzad Kobarfard
Keywords : Compounding, Extemporaneous, Isoniazid, Rifampicin, Stability
Issue Date : April 2015
Abstract :
Objectives: Although liquid dosage forms of antituberculosis drugs can be prepared extemporaneously; the physical and chemical stability of the formulations should always be assessed. At our tuberculosis referral center, isonizid and rifampicin oral liquid forms were compounded for the first time. Our objective was to determine the stability of compounded oral liquid forms of isoniazid and rifampicin. Methods: Isoniazid 10 mg/mL and rifampicin 10 mg/mL were prepared using sorbitol and simple syrup base respectively. The suspensions were then placed in glass bottles and stored at 5C for 28 days. Samples were collected on days 0, 7, 14, 21, and 28 after preparation and analyzed by high performance liquid chromatography. Results: A mean of at least 90% of the initial drug concentration was retained for 28 days after the formulations were made. No substantial changes in the appearance, odor, and uniformity were observed. Conclusion: Isoniazid and rifampicin were stable in liquid dosage forms prepared for 4 weeks during storage at 5C.
Page(s) : 706-709
ISSN : 0975-9492
Source : Vol. 6, No.4