ISSN : 0975-9492


Open Access

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Title : Flow Injection Analysis with Chemiluminescence detection for Determination of Two Phenothiazines
Authors : Hijran S. Jabbar, Azad T. Faizullah
Keywords : Flow injection, Chemiluminescence, Phenothiazines, Pharmaceutical analysis
Issue Date : March 2015
Abstract :
A new flow injection analysis-chemiluminescence (FIA-CL) method for determination of two phenothiazine derivatives "chlorpromazine hydrochloride (CPZ) and promethazine hydrochloride (PTZ)" described. The redox reaction between Fe(III) and phenothiazines was taken as a base of this new method. A well-defined volume of CPZ or PTZ and luminol solution is injected simultaneously by means of two injection valves in accordance with the merging zone principle. Calibration graphs were constructed in the range of (0.05 1.4g/ml) for CPZ with correlation coefficient of (0.9972) and in the range of (0.5 40g/ml) for PTZ with correlation coefficient of (0.9978). The precision and accuracy of the method were checked by calculation of relative standard deviation (RSD) and relative error percentage (%E) for two different levels of concentrations. The method was relatively free from common excipients and it is applied successfully for the determination of CPZ and PTZ in pharmaceutical formulations. The results obtained were in good agreement with those obtained by a reference method in British Pharmacopoeia.
Page(s) : 474-481
ISSN : 0975-9492
Source : Vol. 6, No.3