ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NEW PYRAZOLOPYRIDAZINE DERIVATIVES
Authors : Mahfuz Alam, M.S. Zaman, M.M. Alam, Karun Arora, Aftab Ahmad, Asif Husain
Keywords : Pyridazinone, pyrazole, fused, antibacterial, antifungal
Issue Date : March 2015
Abstract :
Several new pryrazolo-pyridazine derivatives (4a-h) were synthesized through multi-step synthesis and evaluated for their antimicrobial activities. In the first step, 6-phenyl-2,3,4,5-tetrahydropyridazin-3-one (2) was prepared by reacting 4-(4-chlorophenyl)-4-oxobutanoic acid (1) with hydrazine hydrate. Then, aryl-aldehydes were reacted with 2 to furnish pyridazinone derivatives (3a-g). Finally, pyridazinones (3a-h) were reacted with hydrazine hydrate to furnish the title compounds (4a-h). The newly synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against six microbial strains. Compound 4d, 4e and 4f exhibited significant antibacterial action, whereas compound 4c and 4d showed potential antifungal activity. Compound 4d, 5-(4-Chlorophenyl)-3-(4-fluorophenyl)-3,3a,4,7-tetrahydro-2H-pyrazolo[3,4-c]pyridazine, emerged as lead compound having broad spectrum of antimicrobial action.
Page(s) : 495-501
ISSN : 0975-9492
Source : Vol. 6, No.3