ISSN : 0975-9492


Open Access

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Title : Immunosuppressive activity of crude saponins from the leaves of Calotropis gigantea, Calamus roteng and Artocarpus integrifolia
Authors : Amit Gupta, Sushama R Chaphalkar
Keywords : Calotropis gigantea, Calamus roteng and Artocarpus integrifolia
Issue Date : March 2015
Abstract :
Plants can be the ultimate source of various traditional medicines that play an important role in human health care. The objective of our present study is to investigate the immunosuppressive activity of the variable doses of crude saponin (0.625 2.5 mg) extracted from the leaves of Calotropis gigantea, C. rotang and A. integrifolia on lymphocytes, monocytes and granulocytes count and also observed nitric oxide estimation and haemolytic activity using human whole blood. The results showed that the crude saponin extracted from three medicinal plants showed inhibition of monocytes and granulocytes count as compared to control. In addition, these saponins also showed the inhibition of nitric oxide and increase in haemolytic activity at higher doses (2.5 mg) as compared to control. The data suggests that saponins extracted from these medicinal plants i.e. Calotropis gigantea, C. roteng and A. integrifolia showed immunosuppressive activity.
Page(s) : 526-531
ISSN : 0975-9492
Source : Vol. 6, No.3