ISSN : 0975-9492


Open Access

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Title : Effect of Albizia lebbeck on liver and kidney function of Plasmodium berghei infected mice
Authors : Shagun Kalia, Upma Bagai, Varun Gorki
Keywords : Plasmodium berghei, Albizia lebbeck, liver function tests, kidney function tests, histopathological studies.
Issue Date : March 2015
Abstract :
Purpose- Drug resistance to antimalarials has been a major hindrance in the treatment of malaria. The present study was aimed at investigating the biochemical and histopathological effect of ethanolic bark extract of Albizia lebbeck (EBEAL) on Plasmodium berghei infected mice. Methods- To assess the schizonticidal activity, animals were infected with parasite on D0 and orally administered EBEAL concentrations (100-1000 mg/kg; G4-G8) along with normal control (G1), infected control (G2) and CQ, 5mg/kg (G3) respectively. Serum activity of ALP, SGOT, SGPT and levels of bilirubin were assessed as biomarkers of liver function and creatinine and urea as indicators of renal sufficiency on D7. Results -Significant increase (p<0.0001) in enzyme activities of infected control than normal were observed on D7. Serum ALP activity was elevated in G4-G8 while SGOT and SGPT levels were within the normal range contrary to the positive control (CQ) which exhibited significant increase (p< 0.0001) in enzyme activities on D7. In all the extract treated groups, bilirubin levels were slightly elevated. However, kidney function tests were within normal range in treated groups but increased in infected control (G2) on D7. Transverse sections of infected liver illustrated gross lesions whereas slight changes in hepatic architecture were also evident in CQ (5 mg/kg) and EBEAL (100 mg/kg) treated liver exhibiting sinusoidal dilations and haemozoin depositions on D28. This indicates safety of extract to host liver. Necrotic changes in renal morphology was evident in P. berghei infected kidney. CQ treated group exhibited impaired renal morphology, whereas, haemozoin deposition was observed in kidney after EBEAL (100 mg/kg) treatment. Conclusions-The present study has established that administration of EBEAL has no adverse effect on the liver and kidney of mice infected with malaria.
Page(s) : 575-581
ISSN : 0975-9492
Source : Vol. 6, No.3