ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Trypsin inhibiting activity of methanolic extract of aerial parts of Mikania micrantha
Authors : Madhavankutty Jyothilakshmi, Lal Raisa Helen, Mathew Jyothis, Latha Mukalel Sankunni
Keywords : Mikania micrantha, protease inhibiting activity, trypsin, allergy, inflammation
Issue Date : February 2015
Abstract :
Objective: To investigate trypsin inhibiting activity of methanolic extract of aerial parts of Mikania micrantha.Methods: Powdered plant material was extracted with methanol at room temperature and trypsin inhibiting activity of the extract was studied using bovine serum albumin (BSA) as the substrate. Result: Percentage inhibition of trypsin activity by the methanolic extract of aerial parts of Mikania micrantha were 27.330.79, 39.141.02, 48.482.62, 57.403.50 and 70.122.19 respectively for 200,400, 600, 800 and 1000 mg of extract. Conclusion: Agents with trypsin inhibiting activity are emerging drugs to treat allergic and inflammatory diseases. Since Mikania micrantha exhibited excellent trypsin inhibiting activity the plant is a novel source for the development of newer drugs against allergic and inflammatory diseases in traditional as well as modern medicine.
Page(s) : 259-261
ISSN : 0975-9492
Source : Vol. 6, No.2