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ABSTRACT
Title |
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Trypsin inhibiting activity of methanolic extract of aerial parts of Mikania micrantha |
Authors |
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Madhavankutty Jyothilakshmi, Lal Raisa Helen, Mathew Jyothis, Latha Mukalel Sankunni |
Keywords |
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Mikania micrantha, protease inhibiting activity, trypsin, allergy, inflammation |
Issue Date |
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February 2015 |
Abstract |
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Objective: To investigate trypsin inhibiting activity of methanolic extract of aerial parts of Mikania micrantha.Methods: Powdered plant material was extracted with methanol at room temperature and trypsin inhibiting activity of the extract was studied using bovine serum albumin (BSA) as the substrate. Result: Percentage inhibition of trypsin activity by the methanolic extract of aerial parts of Mikania micrantha were 27.33±0.79, 39.14±1.02, 48.48±2.62, 57.40±3.50 and 70.12±2.19 respectively for 200,400, 600, 800 and 1000 mg of extract. Conclusion: Agents with trypsin inhibiting activity are emerging drugs to treat allergic and inflammatory diseases. Since Mikania micrantha exhibited excellent trypsin inhibiting activity the plant is a novel source for the development of newer drugs against allergic and inflammatory diseases in traditional as well as modern medicine. |
Page(s) |
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259-261 |
ISSN |
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0975-9492 |
Source |
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Vol. 6, No.2 |
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