ISSN : 0975-9492


Open Access

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Title : Study of Antifungal Resistance of Candida Types Against Some of Common Antifungus Drugs
Authors : Azim Hasanbeigi, Parasto Shahmir, Mansur Amraie
Keywords : Drug resistance, candida, Oral thrush, diaper dermatitis.
Issue Date : February 2015
Abstract :
Background: Oral Candida and diaper dermatitis are among the most prevalent child diseases that are cured using anti- fungus drugs like Azole and Poly-N. Excessive use leads to some kinds of candida which are resistant to drugs. The aim of this study was to assess the sensitivity of candida isolates separated from oral thrush and diaper dermatitis in children against some of prevalent anti-fungus drugs. Materials and Methods: In this study, 248 samples of oral thrush and diaper dermatitis of the children referring to private clinics and state centers of Ilam city were collected and depending on standard implanting methods, the types of candida were diagnosed. The amount of resistance and sensitivity to Nystatin, fluconazole, ketoconazole and Itraconazole was measured using diffusion disk method according to CLSI M44-A standard. Results: Among the 248 collected samples, the implantations of 149 samples was positive and the most type was that of Candida albicans type. The resistance of candida types to Nystatin, Fluconazole, Ketoconazole and Itraconazole was %6, %37, 37/5, and %47 respectively. Conclusion: the result showed relatively much resistance to Itraconazole and little resistance to Nystatin. Therefore, Nystatin, the best drug to cure diaper dermatitis and oral candida empirically.
Page(s) : 241-244
ISSN : 0975-9492
Source : Vol. 6, No.2