ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTACT OF GLYCOSMIS PENTAPHYLLA IN HYPERLIPIDEMIC WISTAR RATS
Authors : Syed Safiullah Ghori, M.A Rizwan Khan, Kaab e Alam, Abid Hussain Abrar
Keywords : Glycosmis pentaphylla,ethanolic extract,Triton-X ,High Fat Diet, hyperlipidemia,
Issue Date : February 2015
Abstract :
The present study was designed to perform preliminary phytochemical screening, acute oral toxicity and to evaluate antihyperglycemic activity of whole plant of Glycosmis pentaphylla ethanolic extract. .Glycosmis pentaphylla,whole plant was extracted using ethanol as solvent by soxhlet apparatus. The extract was subjected to preliminary phytochemical screening. Acute oral toxicity studies were performed to determine test dose . The evaluation of antihyperlipidemic activity was done using Triton X 100 and High Fat Diet induced hyperlipidemia models in Wistar albino rats. Preliminary phytochemical screening revealed the presence of alkaloids, carbohydrates, glycosides, saponins, tannins, flavonoids, proteins, and amino acids. Doses up to 2000mg/kg were found to be safe after acute toxicity tests. Cholesterol, triglycerides, HDL, LDL, VLDL, SGOT, SGPT, Total protein and glucose were measured. The results suggested that EGP (ethanolic extract.Glycosmis pentaphylla) possess antihyperlipidemic activity against hyperlipidemia induced by Triton X 100 and also High Fat Diet induced experimental models.
Page(s) : 282-292
ISSN : 0975-9492
Source : Vol. 6, No.2