ISSN : 0975-9492


Open Access

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Title : Syzygium Cumini (L.) Seeds Extract Ameliorates Cisplatin Induced Hepatotoxicity in Male Wistar Rats
Authors : R.Maheswari, S.Manohari
Keywords : Cisplatin, Syzygium cumini (L.) seeds, Hepatotoxicity, Hepatoprotective, Free radicals, Antioxidants.
Issue Date : February 2015
Abstract :
The discovery of cisplatin, cis-[Pt(II)(NH(3))(2)Cl(2)] ([PtCl2(NH3)2] or CDDP), was a corner stone which triggered the interest in platinum(II)-and other metal-containing compounds as potential anticancer drugs. Cisplatin, is one of the most potent chemotherapy drugs widely used for cancer treatment. In our present study, an attempt has been made to study the effect of Cisplatin on biochemical and histopathological parameters and ameliorating effects of the Syzygium cumini (L.) aqueous seeds extract or Eugena Jambolana in male wistar rats. Adult male wistar rats were divided into four different groups. Group I Served as vehicle treated normal saline (Control), Group II Rats received single intra-peritoneal (Ip) injection of cisplatin (7mg/kg bw), Group III received Syzygium cumini (L.) aqueous seeds extract 400mg/kg/bw orally for 7 days beginning one day prior to cisplatin (CP) injection. Group IV Rats received alone Syzygium cumini (L.) aqueous seeds extract (400mg/kg bw) treated. Cisplatin exposure leads to adverse effects on hematological, hepatotoxic parameters including Erythrocytes (RBCs). Cisplatin induction leads to reduction in the levels of Enzymic and Non-Enzymic antioxidants levels. However, on treatment with Syzygium cumini (L.) aqueous seeds extract normalized the levels of all the biochemical and hematological parameters. These findings highlight the efficacy of Syzygium cumini (L.) aqueous seeds extract as protective effects Cisplatin induced hepatotoxicity.
Page(s) : 444-450
ISSN : 0975-9492
Source : Vol. 6, No.2