ISSN : 0975-9492


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Title : Prevalence of prediabetes in HIV-1 infected adults receiving antiretroviral therapy in Addis Ababa, Ethiopia.
Authors : Hagos Amare Gebreyesus
Keywords : Prediabetes, HIV-1, ART, overweight
Issue Date : February 2015
Abstract :
Background: Prediabetes is a substantial risk factor for developing type-2 diabetes mellitus and its sequel, which include heart disease, stroke, nephropathy and retinopathy. Apart from the genetic and lifestyle risk factors, antiretroviral drugs aggravate the predisposition. Thus, detecting this condition can allow for the provision of better care for HIV-1-infected patients. Objective: The aim of the study was to determine the prevalence of prediabetes in HIV-1 infected patients on antiretroviral therapy. Method: A cross sectional study was conducted in HIV-1 infected patients enrolled in ART program in a tertiary hospital ART clinic in Addis Ababa. A total of 134 subjects taking HAART were included in the study. 61 (45.5%) were males and 73(54.5%) were females. The age of the participants range from 20-69 with a median of 40 years. The median duration of HAART intake was 58 months. The prevalence of prediabetes was found to be 22.4%. Among the total study subjects, 19.4% of them had overweight. 50.5% of males and 41% females had a WHR of =0.90 and =0.85, respectively indicating a high prevalence of central obesity and future risk of cardiovascular problem among this group. Conclusion: Pre-diabetes is common in HIV-1-infected patients receiving ART; putting this group at substantial risk of developing type 2 diabetes and cardiovascular disease.
Page(s) : 440-443
ISSN : 0975-9492
Source : Vol. 6, No.2