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ABSTRACT
| Title |
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DEVELOPMENT AND VALIDATION OF A UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF LISINOPRIL BOTH IN BULK AND MARKETED DOSAGE FORMULATIONS |
| Authors |
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Vijayalaxmi Chavan, Poonam Phasate |
| Keywords |
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Lisinopril, ICH Q2R1, Distill water, UV spectrophotometer. |
| Issue Date |
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February 2015 |
| Abstract |
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Lisinopril is angiotensin converting enzyme inhibitor widely used in management of blood pressure and congestive heart failure. This study proposes a simple, rapid and economic method of analysis of lisinopril in bulk as well as in formulation using UV spectrophotometer. The present method has been developed in distil water which makes it economic and reproducible. Absorption maxima was obtained at 206nm. The method is validated using ICH Q2R1 guideline for various parameters like precision, accuracy, limit of detection, limt of quantitation etc. Drug follows lineariy in concentration range 10-50 µg/ml with correlation coefficient value (r2) 0.999. The accuracy study was performed by recovery checking at three different concentrations i.e., 80%, 100% and 120 %. The % recovery was found to be in the range 99.27%– 99.95%. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % R.S.D. value less than 2 indicate that the method is precise. The proposed method is a cost-effective quality-control tool for routine analysis of lisinopril in pharmaceutical dosage form. |
| Page(s) |
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394-397 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 6, No.2 |
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