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ABSTRACT
Title |
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RECENT RESEARCH ON ANALYTICAL METHODS OF ANALYSIS OF RALTEGRAVIR AND ELVITEGRAVIR : A REVIEW. |
Authors |
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Pardhi Swati S., Aher Kiran B, Bhavar Girija B., Deshmukh Madhuri D., Chaudhari S.R., Sanjay S. Pekamwar |
Keywords |
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Antiretroviral Drugs, Raltegravir, Elvitegravir, Integrase Inhibitor. |
Issue Date |
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February 2015 |
Abstract |
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Highly Active antiretroviral therapy ( HAART ), a combination drug therapy is a topic of current interest in the treatment of HIV and AIDS. Techniques for the analysis and the quality control of antiretroviral drugs, particularly in the drug combinations are vital in achieving quality of these drugs and the treatments involved. Integrase inhibitor are a class of antiretroviral drug designed to block the action of integrase , a viral enzymes that inserts a viral genome into the DNA of the host cell. Since integration is a vital step in retroviral replication, blocking it can halt further spread of the virus. Integrase inhibitor were initially developed for the treatment of HIV infection . The HPLC,UV and HPTLC methods are available for the analysis of Raltegravir and Elvitegravir, the recently used drug for HIV and AIDS are reviewed in this articles. |
Page(s) |
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369-373 |
ISSN |
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0975-9492 |
Source |
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Vol. 6, No.2 |
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