ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Efficient Synthesis and Therapeutic Evaluation of 1, 3-Thiazolidin-4-ones as Potential Antifungal Agents
Authors : PRADEEP K. SONI AMIT KANKORIYA, A.K. HALVE
Keywords : Thiosemicarbazone, 1,3-thiazolidin-4-one, Disc diffusion method, Antifungal activity.
Issue Date : February 2015
Abstract :
Pathogens immune response to existing pharmaceuticals has risen dramatically in the last few decades due to the structural modifications, genomic mutations and biochemical alterations acquired by the microorganisms. Since many drugs available in the market cause side effects or face quickly developed resistance by the pathogens, there is a general consensus that new antifungal compounds are urgently required for conquering these fungi. Our present work highlights the synthesis and fungal sensitivity evaluation of new thiosemicarbazones (3a-i) and 1, 3-thiazolidin-4-ones (4a-i), obtained using appropriate synthetic methodology. The structures of synthesized compounds were assigned on the basis of elemental and spectral data. All the compounds were tested for sensitivity against a panel of fungal organisms using disc diffusion method. It has been observed that chloro and methoxy moiety in target compounds enhance the antifungal activity.
Page(s) : 417-420
ISSN : 0975-9492
Source : Vol. 6, No.2