ISSN : 0975-9492


Open Access

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Title : Effect Of Cassia Glauca LAMK, Leaves Extract On Cardiovascular And Renal Complications Associated With Streptozotocin-Induced Diabetic Rats
Authors : Zuber J Birajdar, Preeti V Kulkarni, Vishal R Patel, Prashant Delvadia, Md Javeed Y Manure
Keywords : Cassia glauca, anti-diabetic activity, cardio-toxicity, nephro-toxicity.
Issue Date : February 2015
Abstract :
Objective: The present study was designed to evaluate the cardio-protective and nephro-protective potential of ethanolic (CGE) and water extract (CGW) of Cassia glauca leaves. Methods: Type 1 diabetes was induced by single intravenous injection of 45 mg/kg of Streptozotocin (STZ) in male Wistar rats. Rats with fasting blood glucose levels>200mg/dl after seven days of STZ administration were randomized into different groups and were treated with CGE and CGW in graded doses for 56 days. On 52nd day, Intra peritoneal glucose tolerance (IPGTT) test and serum insulin were performed and blood glucose, lipid profiles, cardiac and renal parameters were estimated. In addition, enzymatic and non-enzymatic liver antioxidant levels were also estimated. Results: Treatment with extracts increases the glucose uptake in diabetic rats suggest that the mode of action is like Rosiglitazone. The insulin levels after glucose load and HOMA values suggest that there is no insulin resistance in diabetic rats indicates that rats are under severe diabetic condition (Type1). Supplementation with both doses of CGE and CGW improved glucose tolerance, and insulin tolerance suggesting that, there is an improvement in STZ-induced deleterious effects. In addition, CGE and CGW supplementation decreased oxidative stress by improving endogenous antioxidant levels. Furthermore, administration of CGE and CGW improved diabetic cardio-toxicity and nephro-toxicity. Conclusion: Treatment with CGE and CGW improved cardiac and renal profile. Taken together, these results suggest that CGE and CGW have potent anti-diabetic, cardio-protective, nephro-protective, hypolipidemic and antioxidant activity.
Page(s) : 322-333
ISSN : 0975-9492
Source : Vol. 6, No.2