ISSN : 0975-9492


Open Access

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Title : Antibacterial and Phytochemical Evaluation of the crude extract and Fractions of Fagonia cretica.
Authors : Rumana Saeed, Rashid Iqbal, Hameed Ur Rehman, Nisar Ahmad, Ihsan ul Haq, Zubia Masood, Salman Khurshid, Abid Inayat, M.Mudasar Aslam
Keywords : Phytochemical, Antibacterial activity, Fagonia Cretica,
Issue Date : February 2015
Abstract :
The aim of the present research was to evaluate the antimicrobial potential and phytochemical profile of Fagonia cretica plant to look into possible natural therapy agents. The shade-dried whole plant material of Fagonia cretica was soaked in methanol for 10 days. The powdered drug was extracted with 80 % methanol three times and filtered at room temperature. The filtrate was evaporated in rotary to get a dark-greenish residue (extract), which was further suspended in water and partitioned successively with n-hexane, chloroform, distill water and n-butanol to obtain n-hexane-soluble, chloroform-soluble, distill water-soluble, n-butanol-soluble and aqueous fractions, respectively. Different fractions (chloroform, n-hexane, butanol, water and ethyl acetate) of the plant were tested against various bacterial strains namely E.coli, S.aureus, S.typheae, P.auriginosa.The extracted fractions of the plant exhibit moderate activities showing 9mm to 14mm inhibition against different strains of bacteria as compared to the control, which gave maximum inhibition up to 30mm.The Fagonia cretica was found to be good source of alkaloids, flavonoids, tennins, resins, carbohydrate, starch, proteins, glycosides, coumarin, terponides, steroids and saponine. Anthranol glycosides and starch were absent in the plant. The above results revealed that Fagonia cretica have an excellent anti-bacterial activity and can be used for disease therapy.
Page(s) : 278-281
ISSN : 0975-9492
Source : Vol. 6, No.2