ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : UV Spectrophotometric Determination of Fenofibric Acid By Using Hydrotropy
Authors : V.Niraimathi, A.Jerad Suresh, A.Alageswaran
Keywords : Hydrotropy, Fenofibric acid (FFA); Beer’s law; Standard absorbance method; Derivative spectrophotometry; Area under curve (AUC).
Issue Date : February 2015
Abstract :
Several techniques are used to increase the aqueous solubility of poorly water soluble drugs. Hydrotropic solubilisation technique is one of them. A simple, efficient and new spectrophotometric method has been developed for spectroscopic estimation of fenofibric acid in bulk and tablet dosage forms by using mixed hydrotropic technique. Method A involves the determination of fenofibric acid by standard absorbance method at 299 nm. Method B and Method C involves the determination of fenofibric acid by first derivative spectrophotometry and second derivative spectrophotometry respectively. The normal spectrum was derivatized to first and second order derivative spectrum. The Beer’s concentration was found to be taken 5-30 µg/mL; Method D involves the determination of fenofibric acid by area under curve in the range of 275-316 nm and validated as per ICH guidelines. In present study, 2M urea, and 1M sodium citrate solution were used as mixed hydrotropic agents to enhance the aqueous solubility of the poorly water soluble drug fenofibric acid. It does not interfere in the absorption of drug. Proposed method was validated as per ICH guidelines. The results of validation parameters also indicated that proposed method was found to be accurate, precise, reproducible, sensitive and suitable for routine quality control analysis for estimation of fenofibric acid in bulk and tablet dosage form.
Page(s) : 451-458
ISSN : 0975-9492
Source : Vol. 6, No.2