ISSN : 0975-9492


Open Access

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Title : Development and Validation of First Order Derivative Spectrophotometric method for simultaneous estimation of Nifedipine and Metoprolol Succinate in Synthetic Mixture
Authors : Sojitra Rajanit, Virani Paras, HashumatiRaj
Keywords : Spectroscopic method, First Order Derivativemethod, Nifedipine and MetoprololSuccinate.
Issue Date : February 2015
Abstract :
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of Nifedipine (NIF)and Metoprolol Succinate (MET)in synthetic mixture. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra was obtained in methanol and the determinations were made at 283.80 nm (ZCP of nifedipine) for metoprolol succinate and 242.60 nm (ZCP of metoprolol succinate) for nifedipine. The linearity was obtained in the concentration range of succinate 5-25 g/ml for nifedipine and 25-125g/ml for metoprolol. The mean recovery was 99.64 and 99.41 for Nifedipine and Metoprolol succinate, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of Nifedipine and Metoprolol succinate in synthetic mixture. The results of analysis have been validated statistically and by recovery studies.
Page(s) : 265-272
ISSN : 0975-9492
Source : Vol. 6, No.2