ISSN : 0975-9492


Open Access

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Title : UV Spectrometric Method for the Estimation of Eprosartan mesylate in Bulk and Pharmaceutical Formulation
Authors : Arpan Ramkrushna Ghule, Dattatraya Manohar Shinkar, Ravindra Bhanudas Saudagar
Keywords : Eprosartan mesylate, UV Spectrophotometer, Estimation, Tablet (TEVETEN).
Issue Date : January 2015
Abstract :
In this study, a simple, sensitive and highly accurate ultra-violate spectrophotometric method has been developed and validated for determination of Eprosartan mesylate in bulk and pharmaceutical formulation. The method is based on the measurement of the absorbance of Eprosartan mesylate solution in methanol: phosphate buffer PH 6.8(1:9) at 234nm in the wavelength range of 200-400nm.Beer’s law was obeyed in the concentration range of 10-100 µg/ml.The slope, intercept and correlation coefficient were also calculated. Result of percentage recovery shows that the method was not affected by the presence of common excipients in tablets. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification which proves suitability of proposed method for routine estimation of Eprosartan mesylate in bulk and pharmaceutical formulation.
Page(s) : 70-73
ISSN : 0975-9492
Source : Vol. 6, No.1