ISSN : 0975-9492


Open Access

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Title : Development and Validation of Spectrophotometric Method for Determination of Venlafaxine Hydrochloride
Authors : Bhagyashree A. Pakhale, D M.Shinkar, R B. Saudagar
Keywords : UV-visible spectrophotometer, Method development, Venlafaxine hydrochloride.
Issue Date : January 2015
Abstract :
In these studies describes a simple, accurate, precise and cost effective UV-visible spectrophotometric method for the estimation of Venlafaxine hydrochloride in bulk and pharmaceutical formulations. The method is based on the measurement of absorbance of Venlafaxine hydrochloride solution in 0.1N NaOH at 223nm in the wavelength range of 200-400nm. The method obeys Beer’s Lambert’s law in the selected concentration range 5-25 µg/ml in selected media. The slope, intercept and correlation coefficient were also calculated. Results of percentage recovery study shows that the method was not affected by the presence of common excipients in tablets. The parameters like linearity, precision, accuracy, sensitivity study i.e. Limit of detection and limit of quantitation were studied according to International Conference on Harmonization (ICH) guidelines. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation which proves suitability of proposed method for routine estimation of venlafaxine hydrochloride in bulk and pharmaceutical formulations.
Page(s) : 66-69
ISSN : 0975-9492
Source : Vol. 6, No.1