ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

This website is certified by Health On the Net Foundation. Click to verify.

This site complies with the HONcode standard for trustworthy health information:
verify here.

ABSTRACT

Title : Glassy carbon electrode modified with polyaniline based nanosensors for electrochemical determination of aurone flavonoid
Authors : Dhananjayulu. M, Sivaprasad M, Sreedhar NY
Keywords : aurone, human plasma, polyaniline, differential pulse voltammetry and glassy carbon electrode.
Issue Date : January 2015
Abstract :
The redox characteristics of the flavonoid aurone was determined at glassycarbon electrode (GCE) modified with polyaniline based nanosensors in human plasma. Here the determination of aurone by differential pulse voltammetry (DPV) and cyclic voltammetry (CV). In Phosphate buffer of pH 2.010.0, an irreversible and diffusion-controlled reduction wave was developed. The dependence of the CV response of the developed anodic peak on the sweep rate (?) and on depolizer concentration was typical of an electrode-coupled chemical reaction mechanism (EC) in which an irreversible first-order reaction is interposed between the charges. The values of the electron-transfer coefficient (a) involved in the rate determining step calculated from the linear plots of in the pH range investigated. In Phosphate buffer of pH 5.0, a well defined reduction wave was developed and the plot of peak current height of the DPV against aurone concentration at this peak potential was linear in the range 1.510-6 to 2.2510-3 molL-1 with lower limits of detection (LOD) and quantification (LOQ) of 3.910-9 and 4.510-7 mol L-1, respectively. A relative standard deviation of 1.8% (n=5) was obtained for the flavonoid. These DPV procedures were successfully used for analysis of aurone in human plasma. The method was successfully applied for the determination aurone in human plasma by differential pulse voltammetry using polyaniline doped glassy carbon electrode.
Page(s) : 129-134
ISSN : 0975-9492
Source : Vol. 6, No.1