ISSN : 0975-9492


Open Access

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Title : Stealth Liposomes:A Novel Approach of Targeted Drug Delivery In Cancer Therapy
Authors : Bangale G.S, Rajesh K.S., Shinde G.V.
Keywords : Stealth liposome, Long circulatory liposomes, Polyethylene glycol, PEGylation, Reticoendothelial system, mononuclear phagocytic system etc.
Issue Date : November 2014
Abstract :
Conventional liposomes are artificially prepared vesicles made of a lipid bilayer that can encapsulate drugs and used as a drug carrier system for the treatment of cancer and other diseases. Encapsulation of a drug in liposomes prevents its early degradation and alters the biodistribution profile in the body. This enables higher concentrations of the drug in the desired tumor site, leading to improved effectiveness, and reduced toxicity in the vital organs like heart, kidney etc. Conventional liposomes are eliminated rapidly from the biological fluids (e.g., blood), and therefore lack the stability to establish long circulation times required to realize the full efficacy of the drug. These conventional liposomes are detected by the body first line defense mechanism and phagocytes the liposomes which in turn leads to decrease the liposome concentration and effectiveness of drug. This problem leads in development of long circulatory liposomes which is far better than conventional lipo-somes in stability, efficacy and accuracy in treatment of cancer tissue. These Stealth liposomes recently used in treatment of Kaposiís sarcoma, e.g. DOXIL is marketed FDA Approved drug of Sequus Pharmaceuticals pvt Ltd.19
Page(s) : 750-759
ISSN : 0975-9492
Source : Vol. 5, No.11