ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : DESIGN AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES OF ANTI-INFLAMMATORY DRUG
Authors : Sonali K. Patil, Sourabh R. Joshi, Sachinkumar V. Patil, Shitalkumar S.Patil, Sachin A. Nitave
Keywords : Piroxicam, Mucoadhesive microspheres, Different polymers, evaluation.
Issue Date : November 2014
Abstract :
Oral route of drug administration is the most convenient route of administration, but oral route of drug delivery has certain limitations because of inability to localize the drug at sites of absorption such as gastrointestinal tract. Mucoadhesive microspheres are one of the important novel drug delivery systems which can cause localization of the drug at site of absorption. Bioadhesion is a phenomenon in which two materials at least one of which is biological and are held together by means of interfacial forces. Mucoadhesion is very useful phenomenon because it can improve bioavailability as well as increase patient compliance. A microsphere was prepared by non aqueous emulsification solvent evaporation method by using different polymers such as carbopol 974-P, HPMC K4M, HPMC K100M .Particle size of all microspheres was in the range suitable for administration by GI route. Also the mucoadhesion properties of all microspheres were good. Carbopol has higher mucoadhesion, swelling characters as well as higher entrapment efficiency as compared to HPMC. Whereas HPMC containing batches show higher drug release as compared to Carbopol.
Page(s) : 865-877
ISSN : 0975-9492
Source : Vol. 5, No.11