ISSN : 0975-9492


Open Access

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Title : Protective effects of red wine polyphenols and grape-seed proanthocyanidin extract on acetaminophen-induced liver injury
Authors : El-Sayed M. El-Sayed, Ahmed M. Mansour, Mohamed E. Nady
Keywords : Acetaminophen; Hepatotoxicity; Antioxidant; Red wine polyphenols; Silymarin; Proanthocyanidins
Issue Date : November 2014
Abstract :
The present study was designed to examine the potential protective effects of red wine polyphenols (RWPs) and grape seed proanthocyanidin extract (GSPE) against acetaminophen-induced hepatotoxicity. Silymarin was used as a standard reference hepatoprotective agent. A single dose of acetaminophen (800 mg/kg), injected intraperitoneally to male rats, caused a significant increase in serum ALT, AST, alkaline phosphatase (ALP), bilirubin, total cholesterol (TC), triglycerides(TG), tumor necrosis factor alpha (TNF-a), and liver contents of thiobarbituric acid reactive substances (TBARS) measured as malondialdehyde (MDA) and nitric oxide (NO) with significant decrease in serum albumin, HDL cholesterol, reduced glutathione (GSH) and hepatic activities of catalase (CAT), superoxide dismutase (SOD) and caspase-3 in liver tissue as compared with the control group. On the other hand, administration of each of GSPE (100 mg/kg/day, p.o.), RWPs (40 mg/kg/day, p.o.) and silymarin (100 mg/kg/day, p.o.) for 15 consecutive days significantly ameliorated the liver injury which confirmed by the histopathological examination. It was concluded that RWPs and GSPE showed protective effects against acute acetaminophen hepatotoxicity where RWPs were more effective than GSPE; most probably through their antioxidant, anti-inflammatory and anti-apoptotic effects.
Page(s) : 782-789
ISSN : 0975-9492
Source : Vol. 5, No.11