ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Acute Effect of Fansidar and Antioxidant Vitamin C Co- administration on Serum Lipid profile of Wistar Albino Rats
Authors : Dasofunjo Kayode, Ukpanukpong Richard Undigweundeye, Okwari Obem Obo, Okaba Emmanuel Ojim, Alagwu Emmanuel Ayoma
Keywords : Coronary heart disease, Fansidar (sulpphadoxine and pyrimethamine), Lipid profile,Vitamin C
Issue Date : October 2014
Abstract :
Purpose: Assessment of the lipid profile of fansidar and antioxidant Vitamin C co-administration in albino wistar rats.Methodology: Thirty (30) Wistar albino rats ranging from 175-200g were randomly assigned into six (6) study groups of five (5) rats each Viz: I, II, III, IV, V and VI of ten rats per group. Group I served as male control group. Group II served as female control group. Group III served as male fansidar alone treated group. Group IV served as female fansidar alone treated group. Group V served as male fansidar and Vitamin C treated group while group VI served as female fansidar and vitamin C treated group. Each rat was housed in a wooden cage. The animal room was ventilated and kept at room temperature and relative humidity of 29c and 40-70% respectively with 12 hours natural light-dark cycle and were allowed free access to food and water ad libitum. Good hygiene was maintained by constant cleaning and removal of faeces and spilled from cages daily. Rats in all groups were weighed daily and sacrificed 24hours after the experimental periods of 14 days of oral administration and the serum were collected for lipid profile determination. Results: The body weight parameters of both male and female albino rats, showed significant increase (P<0.05) in both the control groups and fansidar + Vitamin C treated group when compared with their initial weights while the group treated with fansidar alone, showed a significant decrease (P<0.05) in weight when compared with the initial weight for both genders. Likewise, the fansidar treated groups showed a significant increase (P<0.05) in serum cholesterol when compared with the control while the fansidar + Vitamin C treated group showed no significant difference in total serum cholesterol when compared with the control. The group treated with fansidar alone showed a significant decrease in serum HDL when compared with the control while the group treated with fansidar + Vitamin C showed a significant increase when compared with the control. The treated groups also produced a significant (P<0.05) decrease in serum LDL, VLDL and TG when compared with the control. Also, in female albino rats, both treated groups produced a significant (P<0.05) decrease in serum total cholesterol when compared with the control. Though the group treated with fansidar alone produce a significant (P<0.05) decrease in serum HDL, a significant increase (P<0.05) was observed in groups treated with fansidar and antioxidant Vitamin C. The group treated with fansidar alone produce a significant (P<0.05) reduction in serum LDL while groups treated with fansidar and antioxidant Vitamin C produced a significant (P<0.05) increase when compared with the control .Likewise, both treated groups produced a significant (P<0.05) decrease in serum VLDL when compared with the control. The serum triglyceride in fansidar treated group was significantly(P<0.05) decreased in fansidar+ Vit.C treated group when compared with the control. Conclusion:The biochemical alterations and responses above from this study are indications that fansidar and Vitamin C exhibits a synergistic reaction which might aid hypocholesterolaemic effect or cholesterol clearing or lowering ability which can reduce the risk of predisposition to atherosclerosis, coronary heart disease and other cardiovascular related disorders.
Page(s) : 615-621
ISSN : 0975-9492
Source : Vol. 5, No.10